La réalisation d’instruments de mesure électroniques : une intervention didactique pour l’apprentissage interdisciplinaire en science expérimentale, en mathématique et en technologie

Notre recherche de développement en didactique s’est articulée autour de deux pôles : l’engagement actif des élèves dans les paradigmes constructivistes de l’apprentissage par compétences et l’amélioration technologique d’un environnement de laboratoire utilisant la nouvelle technologie des systèmes MicrolabExAO. Pour ce faire, nous nous sommes intéressés aux possibilités didactiques offertes par ce nouvel environnement MicrolabExAO qui permet aux apprenants de réaliser leurs propres instruments de mesure électroniques avec l’expérimentation assistée par ordinateur (ExAO). En développant une intervention didactique appropriée, nous voulions permettre à l’élève non seulement de construire ses instruments, mais aussi d’en comprendre le fonctionnement. Par la réalisation concrète de quatre instruments de mesure, l’élève s’est approprié progressivement une démarche de résolution de problèmes complexes mobilisant des savoirs et savoir-faire en sciences expérimentales, en mathématique et en technologie. Dans l’activité finale de l’intervention didactique, pour vérifier le niveau d’intégration de cette démarche technoscientifique, nous avons demandé aux apprenants de transférer leurs apprentissages en situation nouvelle en construisant un manomètre de manière autonome. Ce faisant, les apprenants ont déployé leurs savoirs et savoir-faire en sciences expérimentales, en mathématique et en technologie pour construire l’instrument de mesure et en expliciter le fonctionnement, effectuant ainsi un apprentissage interdisciplinaire. Comme ils n’ont obtenu aucune directive de la part de l’enseignant ni aucun protocole de manipulations, nous pouvons dire qu’ils étaient placés dans une situation adidactique qui leur a permis de manifester une expertise de traitement interdisciplinaire.Our developmental research in didactics has focused on two distinct aspects : The students' active engagement under the constructivist paradigms of competency-based learning and the technological enhancement of laboratory settings using the new MicrolabExAO environment. Towards these ends, we have explored the teaching possibilities offered by MicrolabExAO which allows learners to design their own electronic measuring tools with the computer assisted experimentation. By developing an appropriated teaching intervention, we wanted to enable the student not only to build his/her tools, but also to understand how they work. Through the actual implementation of four measuring tools, the student has progressively developed his/her own approach to resolving complex problems which call upon knowledge and skills in experimental sciences, mathematics and technology. In the final activity of the teaching intervention, with the objective of assessing the level of integration of this technoscientific approach, we have asked the learners to apply their new knowledge within the framework of building a manometer on their own. In doing so, the learners have deployed their knowledge and skills in experimental sciences, mathematics and technology in order to build the measuring tool and to explain its functioning, thereby achieving interdisciplinary learning. Since they have been given neither instructions from the teacher, nor operating protocols, we can say that they have been put in an adidactical situation which allowed them to demonstrate interdisciplinary expertise in their approach

On the distribution of initial masses of stellar clusters inferred from synthesis models

The fundamental properties of stellar clusters, such as the age or the total initial mass in stars, are often inferred from population synthesis models. The predicted properties are then used to constrain the physical mechanisms involved in the formation of such clusters in a variety of environments. Population synthesis models cannot, however, be applied blindy to such systems. We show that synthesis models cannot be used in the usual straightforward way to small-mass clusters (say, M < few times 10**4 Mo). The reason is that the basic hypothesis underlying population synthesis (a fixed proportionality between the number of stars in the different evolutionary phases) is not fulfilled in these clusters due to their small number of stars. This incomplete sampling of the stellar mass function results in a non-gaussian distribution of the mass-luminosity ratio for clusters that share the same evolutionary conditions (age, metallicity and initial stellar mass distribution function). We review some tests that can be carried out a priori to check whether a given cluster can be analysed with the fully-sampled standard population synthesis models, or, on the contrary, a probabilistic framework must be used. This leads to a re-assessment in the estimation of the low-mass tail in the distribution function of initial masses of stellar clusters.Comment: 5 pages, 1 figure, to appear in ``Young Massive Star Clusters - Initial Conditions and Environments'', 2008, Astrophysics & Space Science, eds. E. Perez, R. de Grijs, R. M. Gonzalez Delgad

An Open System for Social Computation

Part of the power of social computation comes from using the collective intelligence of humans to tame the aggregate uncertainty of (otherwise) low veracity data obtained from human and automated sources. We have witnessed a surge in development of social computing systems but, ironically, there have been few attempts to generalise across this activity so that creation of the underlying mechanisms themselves can be made more social. We describe a method for achieving this by standardising patterns of social computation via lightweight formal specifications (we call these social artifacts) that can be connected to existing internet architectures via a single model of computation. Upon this framework we build a mechanism for extracting provenance meta-data across social computations

Rushes summarization by IRIM consortium: redundancy removal and multi-feature fusion

International audienceIn this paper, we present the first participation of a consortium of French laboratories, IRIM, to the TRECVID 2008 BBC Rushes Summarization task. Our approach resorts to video skimming. We propose two methods to reduce redundancy, as rushes include several takes of scenes. We also take into account low and midlevel semantic features in an ad-hoc fusion method in order to retain only significant content

Utero-vaginal aplasia (Mayer-Rokitansky-Küster-Hauser syndrome) associated with deletions in known DiGeorge or DiGeorge-like loci

<p>Abstract</p> <p>Background</p> <p>Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part of the vagina in women showing normal development of secondary sexual characteristics and a normal 46, XX karyotype. The uterovaginal aplasia is either isolated (type I) or more frequently associated with other malformations (type II or Müllerian Renal Cervico-thoracic Somite (MURCS) association), some of which belong to the malformation spectrum of DiGeorge phenotype (DGS). Its etiology remains poorly understood. Thus the phenotypic manifestations of MRKH and DGS overlap suggesting a possible genetic link. This would potentially have clinical consequences.</p> <p>Methods</p> <p>We searched DiGeorge critical chromosomal regions for chromosomal anomalies in a cohort of 57 subjects with uterovaginal aplasia (55 women and 2 aborted fetuses). For this candidate locus approach, we used a multiplex ligation-dependent probe amplification (MLPA) assay based on a kit designed for investigation of the chromosomal regions known to be involved in DGS.</p> <p>The deletions detected were validated by Duplex PCR/liquid chromatography (DP/LC) and/or array-CGH analysis.</p> <p>Results</p> <p>We found deletions in four probands within the four chromosomal loci 4q34-qter, 8p23.1, 10p14 and 22q11.2 implicated in almost all cases of DGS syndrome.</p> <p>Conclusion</p> <p>Uterovaginal aplasia appears to be an additional feature of the broad spectrum of the DGS phenotype. The DiGeorge critical chromosomal regions may be candidate loci for a subset of MRKH syndrome (MURCS association) individuals. However, the genes mapping at the sites of these deletions involved in uterovaginal anomalies remain to be determined. These findings have consequences for clinical investigations, the care of patients and their relatives, and genetic counseling.</p

A multi-patch use of the habitat: testing the First-Passage Time analysis on roe deer paths

A heterogeneous environment includes several levels of resource aggregation. Individuals do not respond in the same way to this heterogeneity depending on the scale at which they perceive it, and develop different foraging tactics accordingly. The development of methods to analyse animal movements has enabled the study of foraging tactics at several scales. Nevertheless, applied to large vertebrates, these methods have generally been used at large scales, such as for migration trips or the study of marine patches several kilometres large. In this study, we applied a recent method, the First-Passage Time analysis, based on a measure of the foraging effort along the path, to a much finer scale, i.e. under 500 meters. We used 30 daily paths of highly sedentary roe deer females. We modified the initial method, developed by Fauchald and Tveraa (2003), to detect a multi-patch use of the habitat. First-Passage Time analysis results showed that most of the female roe deer exploited their home range as a patchy resource, ranging from 1 to 5 areas of intensive use in their home range. These areas were identified as the most attractive sites within the roe deer female home range. Moreover, this method allowed us to rank the attractive areas according to the time spent in each area. Coupled with habitat selection analysis to identify what makes these areas attractive, the First-Passage Time analysis should offer a suitable tool for landscape ecology and management

Methyl mercury dynamics in a tidal wetland quantified using in situ optical measurements

Author Posting. © American Society of Limnology and Oceanography, 2011. This article is posted here by permission of American Society of Limnology and Oceanography for personal use, not for redistribution. The definitive version was published in Limnology and Oceanography 56 (2011): 1355-1371, doi:10.4319/lo.2011.56.4.1355.We assessed monomethylmercury (MeHg) dynamics in a tidal wetland over three seasons using a novel method that employs a combination of in situ optical measurements as concentration proxies. MeHg concentrations measured over a single spring tide were extended to a concentration time series using in situ optical measurements. Tidal fluxes were calculated using modeled concentrations and bi-directional velocities obtained acoustically. The magnitude of the flux was the result of complex interactions of tides, geomorphic features, particle sorption, and random episodic events such as wind storms and precipitation. Correlation of dissolved organic matter quality measurements with timing of MeHg release suggests that MeHg is produced in areas of fluctuating redox and not limited by buildup of sulfide. The wetland was a net source of MeHg to the estuary in all seasons, with particulate flux being much higher than dissolved flux, even though dissolved concentrations were commonly higher. Estimated total MeHg yields out of the wetland were approximately 2.5 µg m−2 yr−1—4–40 times previously published yields—representing a potential loading to the estuary of 80 g yr−1, equivalent to 3% of the river loading. Thus, export from tidal wetlands should be included in mass balance estimates for MeHg loading to estuaries. Also, adequate estimation of loads and the interactions between physical and biogeochemical processes in tidal wetlands might not be possible without long-term, high-frequency in situ measurements.This work was supported by funding from the California Bay Delta Authority Ecosystem Restoration and Drinking Water Programs (grant ERP-00-G01) and matching funds from the U.S. Geological Survey Cooperative Research Program

Mercury Dynamics in a San Francisco Estuary Tidal Wetland: Assessing Dynamics Using In Situ Measurements

We used high-resolution in situ measurements of turbidity and fluorescent dissolved organic matter (FDOM) to quantitatively estimate the tidally driven exchange of mercury (Hg) between the waters of the San Francisco estuary and Browns Island, a tidal wetland. Turbidity and FDOM-representative of particle-associated and filter-passing Hg, respectively-together predicted 94 % of the observed variability in measured total mercury concentration in unfiltered water samples (UTHg) collected during a single tidal cycle in spring, fall, and winter, 2005-2006. Continuous in situ turbidity and FDOM data spanning at least a full spring-neap period were used to generate UTHg concentration time series using this relationship, and then combined with water discharge measurements to calculate Hg fluxes in each season. Wetlands are generally considered to be sinks for sediment and associated mercury. However, during the three periods of monitoring, Browns Island wetland did not appreciably accumulate Hg. Instead, gradual tidally driven export of UTHg from the wetland offset the large episodic on-island fluxes associated with high wind events. Exports were highest during large spring tides, when ebbing waters relatively enriched in FDOM, dissolved organic carbon (DOC), and filter-passing mercury drained from the marsh into the open waters of the estuary. On-island flux of UTHg, which was largely particle-associated, was highest during strong winds coincident with flood tides. Our results demonstrate that processes driving UTHg fluxes in tidal wetlands encompass both the dissolved and particulate phases and multiple timescales, necessitating longer term monitoring to adequately quantify fluxes

Spinocerebellar ataxia 27B: episodic symptoms and acetazolamide response in 34 patients

Ashton C et al report a retrospective multi-centre cohort of 34 patients from Canada, France, Austria and Australia with spinocerebellar ataxia 27B, describing the common feature of episodic ataxia and other episodic features, as well as the inefficacy of acetazolamide in these patients